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The vertical lines between the eyebrows are usually called glabellar lines, frown lines, or simply the 11 lines. They are among the earliest expression-driven wrinkles patients notice because they can make the face look tense, tired, or angry even at rest.
Botox in this area works by reducing the pull of the corrugator and procerus muscles. Done well, the goal is not to erase personality. The goal is to soften excessive tension while keeping the upper face balanced and natural.
The glabella sits in a high-mobility central zone of the face. Repeated frowning, concentrating, squinting, and sun-driven collagen loss all make these lines deepen faster than many patients expect.
At first the lines are dynamic and only appear during expression. With time they can become static and remain visible even when the face is relaxed. That is why early treatment often works better than waiting until the fold becomes deeply etched.
In clinical practice the treatment is typically built around a central point pattern across the procerus and both corrugators. The exact number of units should not be copied from the internet because muscle mass, brow position, sex, previous toxin history, and asymmetry all matter.
A conservative plan is safer than an aggressive one. If too much toxin is placed too low or too medially, the risk of heavy brows or eyelid ptosis increases. Precise anatomy matters much more than chasing a fixed dose chart.
Dr. Gemici: The best glabella treatment should make the patient look calmer, not different. If the area is overtreated, the face quickly starts to lose its natural upper-third harmony.
For dynamic 11 lines, Botox alone is often sufficient. For older patients with deeply carved static lines, toxin may relax the muscle but not fully erase the crease that has already settled into the skin.
In those cases I may discuss a staged plan that can include skin quality treatment, fractional laser, RF-based remodeling, or in selected patients a very careful filler strategy. The muscle component and the skin component are not always the same problem.
The common short-term effects are small bumps, mild redness, or a tiny bruise. The more important discussion is about technique-related risk: brow heaviness, asymmetry, or eyelid ptosis when the product diffuses where it should not.
After treatment I advise patients to avoid rubbing the area, heavy exercise, sauna, and lying fully face-down for the first several hours. Results usually begin within a few days and settle over 10 to 14 days.
There is no single correct number for everyone. The dose depends on anatomy, muscle strength, asymmetry, and the physician’s injection plan.
Yes, ptosis is a known but uncommon risk when technique or placement is poor. That is why glabella treatment should be performed by an experienced physician.

Trusted & Professional
Dr. Hamza Gemici is a medical aesthetic physician based in Ataşehir, Istanbul. His practice focuses on natural anti-aging and subtle facial harmonization using botulinum toxin, dermal fillers, periocular rejuvenation and skin quality procedures. All treatments are performed with FDA-approved products under physician-guided protocols.