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Quick Summary · TL;DR
Nasolabial folds are often a visible consequence of volume loss and tissue descent above the fold, not just a line that should be filled directly. Good treatment usually begins by assessing the cheek, pyriform aperture, and overall facial support. Direct fold filler may still be used, but only after the facial framework is understood.
Key Takeaways
Patients often point to the fold beside the nose and ask for it to be filled. Anatomically, that line is frequently the final visible result of changes happening above it rather than a problem that starts inside the fold itself.
That is why my first question is not how much product the line needs, but why the line became deep in that particular face.
Loss of deep medial cheek support, descent of the malar fat pad, ligament weakness, and maxillary support change all contribute to a more dramatic fold. The fold may therefore reflect a larger midface story rather than an isolated crease.
Some younger patients still have a strong native fold anatomy, but in aging faces the line usually sits inside a broader support problem.
If the cheek and pyriform region are not assessed first, direct fold filler can create a swollen or puffy look near the nose and upper lip. The line may still move when the patient smiles, but now it sits on top of extra volume.
For that reason I often start with midface support, then reassess whether direct fold treatment is still necessary and how much is actually appropriate.
More structural areas may need a firmer product, while the fold itself may need a softer approach if it is treated directly. But regardless of product, the nasolabial region remains a vascular caution zone.
That means slow injections, small aliquots, and a plan that prioritizes anatomy over speed. Patients should understand that improvement is the goal, not total erasure at any cost.
Dr. Gemici: A deep nasolabial fold is usually telling you a story about the midface. If you only fill the line, you often miss the real diagnosis.
No. In many patients cheek or pyriform support should be evaluated first because the fold is a consequence of support loss above it.
Because the line still moves dynamically, and adding too much product into the fold can create puffiness near the nose and upper lip.
Yes. The perinasal region requires careful vascular awareness and conservative technique.

Trusted & Professional
Dr. Hamza Gemici is a medical aesthetic physician based in Ataşehir, Istanbul. His practice focuses on natural anti-aging and subtle facial harmonization using botulinum toxin, dermal fillers, periocular rejuvenation and skin quality procedures. All treatments are performed with FDA-approved products under physician-guided protocols.