Mesotherapy
Mesotherapy is a treatment that improves skin quality by injecting mixtures of vitamins, minerals, amino acids, and hyaluronic acid into the middle layer of skin. It provides skin hydration, radiance, and improved elasticity.
Treatment Information
Duration
30-45 minutes
Body Location
Face, neck, décolletage, hands or selected skin areas after assessment
Preparation
Avoid alcohol and blood thinners 24 hours before. Keep your skin clean.
Follow-up Care
Mild redness and swelling may persist 24-48 hours. Protect from sun and use SPF 50+.
How It Is Performed
Vitamin, mineral, and hyaluronic acid mixture is injected into the middle layer of skin using fine needles or mesogun.
Mesotherapy vs Rejuvenation Injection: Picking the Right Skin Booster
"Rejuvenation injection" is used colloquially for both classic mesotherapy cocktails and cross-linked HA biostimulators (e.g., Profhilo, Skinbooster). Both are delivered to the mesoderm but differ in target, ingredients, and protocol.
| Criterion | Classic Mesotherapy Cocktail | Rejuvenation Injection (HA Biostimulator) |
|---|---|---|
| Formulation | Hyaluronic acid + amino acids + vitamins + trace elements + antioxidants (personalised cocktail) | High molecular weight, lightly cross-linked stable HA (e.g., Profhilo, Skinbooster) |
| Primary Target | Replenishes skin hydration and nutrients, boosts superficial glow and luminosity | Stimulates collagen and elastin, remodels the skin structurally from within ("bioremodelling") |
| Injection Depth | Superficial dermis (0.5–1 mm) — many micro-points | Deep dermis / subdermis — 5–10 bolus points (BAP technique) |
| Protocol | 4 sessions, 10–15 days apart; 1–2 cycles per year | 2 sessions, 4 weeks apart; maintenance twice yearly |
| Effect Duration | 3–6 months after series | 6–9 months; cumulative improvement with regular cycles |
| Best Suited For | Dull, tired appearance, dehydrated skin | Laxity, wrinkle tendency, loss of firmness (35+) |
| Pain / Comfort | Moderate — many micro-punctures; topical anaesthetic suffices | Mild — few entry points, usually tolerated without anaesthetic |
Dr. Gemici's Recommendation
For surface glow, hydration, and "holiday skin" in ages 25–35, classic mesotherapy shines; for 35+ with laxity, thinning tissue, or wrinkle tendency, HA biostimulators win. In my clinic I often sequence them in the same protocol for layered results.
Frequently Asked Questions
Usually 4-6 sessions recommended, applied every 2-4 weeks. Then maintenance sessions.
Minimal discomfort due to very fine needles. Anesthetic cream can be applied if desired.
Yes, hair mesotherapy nourishes and strengthens hair follicles. Very effective in early hair loss.
Pregnancy, nursing, active skin infections, severe bleeding disorders are contraindications.
Injection site redness, mild swelling, bruising normal 24-48 hours. Rarely granulomas.
Yes, but Fitzpatrick V-VI has slightly higher post-inflammatory hyperpigmentation risk. Doctor aware.
Mesotherapy: vitamin/mineral cocktail, lighter. Profhilo: pure HA, deeper, more effective. Can combine both.
Mesotherapy — Related Medical Terms
Deep-dive in our glossary: definition, indications, side effects and FAQs.
Hyaluronic Acid
Hyaluronic acid (HA), the active ingredient used in dermal fillers, is a high molecular weight glucosaminoglycan polymer composed of β-1,4-D-glucuronic acid and β-1,3-N-acetyl-D-glucosamine repeating disaccharide, occurring naturally in the body; It is the most commonly used filler in facial filler in aesthetic injections, increasing skin hydration and volumetricity.
Peptide Serum
Peptide serum are cosmeceutical active substances consisting of short-chain amino acid sequences (typically 2-50 amino acids, mostly 3-6), which trigger collagen and elastin synthesis, inhibit neurotransmitter release or prevent enzymatic degradation; They form the main component of the bulk in topical serum formulations used against signs of aging (wrinkles, loss of skin tension, fine lines).
Vitamin C Serum
Vitamin C serum is a cosmeceutical serum formulation containing L-ascorbic acid or its derivatives (sodium ascorbyl phosphate, magnesium ascorbyl phosphate, tetrahexyldecyl ascorbate); It is a dermocosmetic topical product class that provides anti-aging, brightening and UV protective effects with its antioxidant, collagen synthesis stimulating and melanin inhibition properties.
Niacinamide
Niacinamide (nicotinamide) is the amide form of Vitamin B3 and is the active ingredient in cosmeceutical serums that strengthens the skin barrier, provides sebum regulation, inhibits melanin transfer and supports collagen synthesis; As a NAD+/NADP+ precursor, it is active in cellular energy metabolism.
Microneedling RF (Fractional RF Microneedling)
Microneedling RF (Fractional RF Microneedling) is a category of fractional skin resurfacing devices that deliver bipolar radiofrequency energy through an insulated or non-insulated micro-needle array (25–64 pins) at a dermal depth of 0.5–3.5 mm, FDA-approved for the treatment of acne scars, striae (stretch marks) and superficial rhytids, marketed under multiple brands such as Vivace/Secret RF/Infini/EndyMed.
Filler
Filler; They are biocompatible materials that are injected into selected areas of the face, restore volume loss, fill static lines and improve facial contour, and have varieties such as hyaluronic acid, calcium hydroxyapatite, poly-L-lactic acid and autologous oil.
Neck Rejuvenation
Against platysmal bands, horizontal wrinkles and pigmentation problems of the neck area; Multimodal aesthetic procedure with a combination of botox, hyaluronic acid, biostimulators and laser.
retinol
Retinol is the pre-vitamin form of Vitamin A1 (C20H30O), which is metabolized into retinal and retinoic acid in the skin and provides increased cellular turnover, collagen synthesis stimulation, melanin inhibition and anti-photoaging effects through nuclear receptors, and is the gold standard anti-aging active ingredient of the cosmetic industry.
tonic
Toner is a liquid product that balances the pH of the skin after cleansing and acts as a residue cleaner. It is divided into the categories of traditional astringen (alcohol-based, for aged skin) vs modern hydration tonic (glycerin + hyaluronic acid) vs exfoliating tonic (AHA 4-7%, BHA 2% — active exfoliating agent).
Hair Mesotherapy
Hair Mesotherapy is a medical aesthetics term related to treatments planned for specific face or body areas. In Dr. Hamza Gemici's glossary, it is explained as a patient-education topic for understanding indications, planning, recovery, and safety before consultation.
Sources & Regulatory Authorities
Information sourced from official regulatory authority databases (FDA, EMA, TİTCK) and peer-reviewed medical literature. Not a substitute for medical advice; clinical decisions are always individualized.
Product Approvals (FDA / EMA / TİTCK)
- TİTCK
Scientific References (PubMed / Cochrane)
- El-Domyati M, El-Ammawi TS, Moawad O, et al.. Mesotherapy for facial skin rejuvenation: a clinical, histologic, and electron microscopic evaluation · Dermatol Surg (2012)
Related Services
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