Yes — botulinum toxin is generally safe in patients over 50, and many clinical studies have shown comparable safety and efficacy to younger cohorts. The main considerations are: (1) muscle atrophy may have started, so lower doses with finer titration are preferred; (2) ptosis risk is slightly higher in patients with pre-existing brow asymmetry — a careful clinical exam mitigates this; (3) skin laxity is not addressed by Botox alone, so a combination protocol with biostimulators or fillers usually delivers a more natural result.