What is regeneration?
In aesthetic medicine, the concept of regeneration has begun to take precedence over the concept of filling in the last decade. The essence of regeneration is to stimulate the skin's own repair mechanisms and support its natural production (collagen, elastin, hyaluronic acid). In this approach, we put a substance into the skin, but the main work is done by the skin itself; because molecules that signal the cell are used.
Polynucleotides (e.g., DNA fragments), autologous blood products (PRP, PRF), growth factors, and some peptide cocktails fall into this category. None of these products cause an instant change in shape; but they significantly improve the internal quality of the skin within weeks.
The rise of polynucleotides
Polynucleotide-based injections have gained significant clinical use in the last five years. They offer a safe regenerative tool, especially for delicate and difficult areas — under-eye, forehead, neck. Their molecular mechanism is to stimulate fibroblasts and increase cell repair.
In the clinic, I especially prefer polynucleotides for under-eye dark circles and fine wrinkles; because they do not carry the Tyndall effect that occurs when hyaluronic acid filler is applied incorrectly and do not disturb naturalness. They can also be combined with filler; but often, their use alone is satisfying.
Clinical note:Regenerative treatments are not suitable for impatient patients. This approach, which requires investment and patience, postpones the skin's aging curve for years when it meets the right patient.
Realistic timeline
The effect of regenerative sessions begins to appear not in the first week, but in the 3rd-4th week, and develops with a cumulative curve of 3-6 months. Therefore, I clearly explain to my patients "do not expect results with one session". This approach is not a trendy "glow", but a structural repair; it takes its time.
The change we see in my patients' skin with well-executed regenerative plans over the years cannot be compared with single-session procedures. Especially in the 40+ age group, the regenerative approach is the silent but most powerful competitor of filler.
- Polynucleotide injections — focused on skin repair.
- PRP — growth factor gain from blood platelets.
- PRF — a more stable, long-release form of plasma.
- Growth factor ampoules — topical support.
- Meso-cocktails — vitamin-amino acid combinations.